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Differences between Dihydropyridine and Nondihydropyridine

Differences between Dihydropyridine and Nondihydropyridine

Dihydropyridine (DHP) and nondihydropyridine (NDP) calcium channel blockers are two types of medications used to treat high blood pressure. Although they both work by blocking calcium channels, DHP medications are more potent and have a longer duration of action. For this reason, DHP medications are generally prescribed for people with more severe high blood pressure. However, NDP medications may be better suited for some people because they have fewer side effects. Your doctor can help you decide which type of medication is best for you.

What is Dihydropyridine?

Dihydropyridine is a type of organic compound that is typically used as a vasodilator. It works by relaxing the smooth muscles in the walls of blood vessels, which helps to widen the vessels and improve blood flow. Dihydropyridine is also sometimes used to treat certain types of heart arrhythmias. In addition, dihydropyridine has been shown to have some protective effects on the brain, and it is being investigated as a potential treatment for Alzheimer’s disease and other forms of dementia. Dihydropyridine is generally well-tolerated, but some side effects have been reported, including headaches, dizziness, and flushing.

What is Nondihydropyridine?

Nondihydropyridine is a type of drug that is used to treat heart conditions. It works by blocking calcium channels in the heart, which helps to improve blood flow and reduce congestion. Nondihydropyridine is typically used in combination with other medications, and it is generally well-tolerated with few side effects. However, some people may experience dizziness, headache, or nausea. Nondihydropyridine is available in both oral and intravenous forms, and it should be taken as directed by your healthcare provider.

Differences between Dihydropyridine and Nondihydropyridine

  • Dihydropyridine and nondihydropyridine agents act on different calcium channels in the body. Dihydropyridines block L-type voltage-sensitive calcium channels found in arterial smooth muscle, whereas nondihydropyridines preferentially block T-type calcium channels found mostly in cardiac tissue and CNS neurons.
  • Dihydropyridines cause more arterial dilation than nondihydropyridines, which can result in higher blood pressure. Dihydropyridines also have greater negative inotropic effects and may cause more heart failure than nondihydropyridines.
  • In addition, dihydropyridines can cause more tachycardia than nondihydropyridines. Dihydropyridines are metabolized more slowly than nondihydropyridines and can accumulate in the body, which can increase the risk of side effects. Diltiazem and verapamil are examples of nondihydropyridine calcium channel blockers whereas amlodipine and felodipine are examples of dihydropyridine calcium channel blockers.


Dihydropyridine and nondihydropyridine are two types of calcium channel blockers. They both have different mechanisms by which they work, and this can affect how they are used in the treatment of hypertension. Your doctor will be able to determine which type of calcium channel blocker is best for you.

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