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Differences between Cyanocobalamin and Hydroxocobalamin

Differences between Cyanocobalamin and Hydroxocobalamin

When it comes to vitamin B12, there are two main types: cyanocobalamin and hydroxocobalamin. While both have their own benefits, there are some key differences between the two that you should know. In this blog post, we’ll discuss what those differences are, as well as when it might be better to take one over the other. So, whether you’re just starting to learn about vitamin B12 or you’re looking for more information on cyanocobalamin vs hydroxocobalamin, keep reading!

What is Cyanocobalamin?

Cyanocobalamin is a water-soluble vitamin that plays an important role in the body’s metabolism. The body needs cyanocobalamin to produce red blood cells and maintain a healthy nervous system. Cyanocobalamin is found in food and supplements, and it can also be made in the laboratory. Cyanocobalamin is generally well tolerated, but some people may experience side effects such as headaches, dizziness, or nausea. Cyanocobalamin is an important vitamin for the human body, and it is important to get enough of this vitamin through diet or supplementation.

What is Hydroxocobalamin?

  • Hydroxocobalamin is a water-soluble vitamin that is typically used to treat vitamin B12 deficiency. The body needs vitamin B12 to produce healthy red blood cells and prevent anemia.
  • Hydroxocobalamin is also used to treat other conditions, such as nerve damage, diabetic neuropathy, and certain types of cancer. Hydroxocobalamin is available in injectable form and as a sublingual tablet.
  • Hydroxocobalamin injections are usually given intramuscularly or intravenously. Hydroxocobalamin tablets are typically dissolved under the tongue. Hydroxocobalamin should not be taken by mouth. Hydroxocobalamin can have side effects, such as nausea, vomiting, diarrhea, and headaches. Hydroxocobalamin can also cause allergic reactions. Talk to your doctor about the risks and benefits of taking hydroxocobalamin.

Differences between Cyanocobalamin and Hydroxocobalamin

  • Cyanocobalamin and hydroxocobalamin are two different forms of vitamin B12. Cyanocobalamin is the form of B12 that is most commonly found in supplements, while hydroxocobalamin is the form found naturally in food.
  • Cyanocobalamin is converted into hydroxocobalamin in the body, and both forms are then stored in the liver. Cyanocobalamin is generally considered to be more stable than hydroxocobalamin, and it has a longer shelf life.
  • However, hydroxocobalamin is thought to be better absorbed by the body, making it the preferred form for people with absorption problems. Cyanocobalamin can also be used to treat some medical conditions, such as pernicious anemia, while hydroxocobalamin is not as effective for this purpose. Ultimately, both forms of B12 are necessary for good health, so it is important to get enough of both through diet and supplementation.


Hydroxocobalamin is a better form of B12 for several reasons. If you are not getting enough B12 in your diet, or if you have absorption issues, then it is worth asking your doctor about switching to hydroxocobalamin. Cyanocobalamin is still the most common form of B12 supplements, but with more and more research showing the benefits of hydroxocobalamin, that may start to change soon.

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