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Difference between Zyrtec and Benadryl

Difference between Zyrtec and Benadryl

Both Zyrtec and Benadryl are antihistamines that are used to relieve allergy symptoms, but they work in different ways. Zyrtec is a newer drug that blocks histamine from binding to cells in the body, while Benadryl is an older drug that inhibits the action of acetylcholine, which helps to reduce inflammation. Although both drugs are effective at treating allergies, Zyrtec may be a better choice for some people because it has fewer side effects.

What is Zyrtec?

Zyrtec is a medication that is used to treat allergies. It works by blocking the body’s histamine response to allergens. Zyrtec is available in both over-the-counter and prescription forms. The over-the-counter version is intended for people who have mild allergies, while the prescription version is for people who have more severe allergies. Zyrtec is generally well tolerated, but some side effects may occur, such as dry mouth, drowsiness, and fatigue. Zyrtec should not be used by people who are pregnant or breastfeeding.

What is Benadryl?

Benadryl is an over-the-counter antihistamine that is used to treat allergies. It works by blocking histamine, a substance produced by the body in response to allergens. Benadryl is available in both pill and liquid form and can be taken with or without food. Common side effects include drowsiness, dry mouth, and dizziness. Benadryl should not be taken with alcohol or other sedatives. Benadryl is not recommended for use in children under the age of 2. For more information, please consult your healthcare provider.

Difference between Zyrtec and Benadryl

  • Zyrtec and Benadryl are two common over-the-counter medications used to treat allergy symptoms. Both medications can be effective in treating symptoms such as sneezing, runny nose, and watery eyes. However, there are some key differences between the two drugs.
  • Zyrtec is a longer-acting medication and is typically taken once daily. It takes effect within 1-3 hours after taking the medication. Benadryl is a shorter-acting medication and is typically taken every 4-6 hours as needed.
  • It takes effect within 30 minutes after taking the medication. Zyrtec is also less likely to cause drowsiness than Benadryl. Therefore, Zyrtec may be the better option for people who need to avoid drowsiness during the day. Both medications are available over-the-counter and do not require a prescription from a doctor.


Although Benadryl is a common over-the-counter allergy medication, it may not be the best option for everyone. Zyrtec is another popular antihistamine that can provide relief from allergy symptoms.

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