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Difference between Scleroderma and Crest

Difference between Scleroderma and Crest

When most people hear the word “scleroderma”, they think of an autoimmune disorder that causes hard, scaly skin. However, there is another type of scleroderma called CREST syndrome, which is a group of symptoms that are associated with limited blood flow to certain parts of the body. While both conditions have some overlapping symptoms, there are also some key differences between scleroderma and Crest syndrome. In this blog post, we will explore those differences in more detail.

What is Scleroderma?

Scleroderma is a condition that results in the hardening and thickening of the skin. It can also affect the internal organs, including the lungs, heart, and digestive system. Scleroderma is caused by the overproduction of collagen, a protein that helps to support the skin and connective tissues. In people with scleroderma, the collagen builds up in patches, causing the skin to become thick and puffy. The condition can also cause blood vessels to constrict, which can lead to organ damage. Scleroderma is a chronic condition that has no cure, but treatments are available to help manage the symptoms. Early diagnosis and treatment is essential for preventing serious complications.

What is Crest?

Crest is a condition that results in the overgrowth of connective tissue. This can occur in any part of the body, but is most often seen in the hands, feet, and face. The excess tissue can cause the affected area to appear swollen and misshapen. In severe cases, it can impair movement and cause pain. There is no cure for crest, but treatment can help to manage symptoms and slow the progression of the condition. Early diagnosis and treatment are essential for preventing complications. If you or someone you know has crest, it is important to seek medical care as soon as possible.

Difference between Scleroderma and Crest

  • Scleroderma and Crest are two conditions that affect the connective tissues. Scleroderma results in the hardening and thickening of the skin, while Crest causes the calcification of blood vessels. Both conditions can lead to organ damage and disability, but they differ in their symptoms and treatment options.
  • Scleroderma is more common in women and tends to affect the hands, face, and chest. The skin may become tight, shiny, and thin, and small blood vessels may disappear. Joints may become stiff, and breathing may be difficult.
  • There is no cure for scleroderma, but treatments can help improve symptoms. Crest is more common in men and often affects the heart and lungs. Symptoms include fatigue, shortness of breath, and chest pain. Treatment options include surgery, radiation therapy, and drug therapy. While there is no cure for Crest, early diagnosis and treatment can help prevent serious complications.


Crest and Scleroderma are both diseases, but they have different effects on the body. Crest is a dental disease that affects the teeth and gums, while Scleroderma is a rare autoimmune disease that affects the skin, blood vessels, and other organs. If you are experiencing any of the symptoms associated with either of these diseases, it is important to see a doctor for diagnosis and treatment.

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