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Difference between NPH and Regular Insulin

Difference between NPH and Regular Insulin

Insulin is a hormone that is produced in the pancreas. Insulin helps the body to use glucose (sugar) for energy. There are different types of insulin, and each type works differently. For people with diabetes, it is important to know about the different types of insulin and how they work. This article will discuss the difference between NPH and regular insulin.

What is NPH Insulin?

NPH Insulin is a long-acting insulin that is derived from pork and beef sources. NPH stands for N neutral protamine Hagedorn. NPH insulin has a slower onset and a longer duration of action when compared to regular human insulin. NPH insulin peaks in 4-12 hours but can last up to 24 hours. NPH insulin is used to help control blood sugar levels in people with diabetes.

NPH insulin is usually taken once or twice a day, depending on the person’s needs. NPH insulin can be used in combination with other types of insulin or oral diabetes medications. NPH insulin may cause low blood sugar levels (hypoglycemia). Symptoms of hypoglycemia include shakiness, sweating, confusion, and headache. NPH insulin should be used with caution in people with diabetes who are also taking corticosteroids or other medications that can cause low blood sugar levels. NPH insulin should not be used during pregnancy or breastfeeding.

What is Regular Insulin?

Regular insulin is a type of insulin that is used to control blood sugar levels in people with diabetes. It is typically taken three times a day, before meals. Regular insulin is short-acting insulin, which means that it starts working within 30 minutes and peaks at 2-4 hours. Regular insulin can be used alone or in combination with other diabetes medications. It is important to follow the instructions of your healthcare provider when taking regular insulin.

Difference between NPH and Regular Insulin

NPH (Neutral Protamine Hagedorn) and regular insulin are both types of short-acting insulin. NPH is cloudy insulin that has been combined with protamine, while regular insulin is a clear insulin. NPH begins working about two hours after injection and peaks at four to twelve hours. Regular insulin begins working about thirty minutes after injection and peaks at two to four hours. NPH is typically dosed once or twice daily, while regular insulin is typically dosed three to four times daily. NPH is used to treat diabetes mellitus type 1 and type 2, while regular insulin is used to treat diabetes mellitus type 1 only.


NPH and Regular Insulin are both used to treat diabetes, but they work in different ways. NPH insulin is a long-acting insulin that starts working about 2 hours after you take it, and it lasts for up to 24 hours. Regular insulin starts working right away, and its effects wear off within 3 to 5 hours. If you’re not sure which type of insulin is best for you, talk to your doctor or pharmacist. They can help you choose the right one and figure out the correct dosage.

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