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Difference between Ibuprofen and Naproxen

Difference between Ibuprofen and Naproxen

Both ibuprofen and naproxen are nonsteroidal anti-inflammatory drugs (NSAIDs) that are often used to relieve pain and inflammation. However, there are some key differences between these two medications. Ibuprofen is available over the counter, while naproxen is a prescription medication. Naproxen is also more potent than ibuprofen and can be more effective at relieving inflammation. Additionally, naproxen has been associated with a lower risk of gastrointestinal problems than ibuprofen. If you are experiencing pain or inflammation, talk to your doctor to see if naproxen is right for you.

What is Ibuprofen?

Ibuprofen is a medication that belongs to a class of drugs known as non-steroidal anti-inflammatory drugs (NSAIDs). Ibuprofen works by reducing inflammation, pain, and fever. It is available over-the-counter (OTC) and as a generic drug. The brand names for ibuprofen include Advil and Motrin. Ibuprofen is used to treat a variety of conditions, including headaches, muscle aches, arthritis, menstrual cramps, and reducing fever. Ibuprofen can be taken with or without food. Common side effects of ibuprofen include upset stomach, heartburn, diarrhea, constipation, bloating, gas, dizziness, lightheadedness, and headache. Ibuprofen can also cause gastrointestinal bleeding and ulcers. More serious side effects include kidney damage and an increased risk of heart attack or stroke. Ibuprofen should be used with caution in people with heart disease or other risk factors for heart disease. Ibuprofen should not be taken late in pregnancy.

What is Naproxen?

Naproxen is a medication that belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). Naproxen is used to relieve pain from various conditions such as headache, dental pain, menstrual cramps, arthritis, or other types of pain. Naproxen is also used to reduce fever. Naproxen works by reducing inflammation and swelling. Naproxen should be taken with food or milk to avoid stomach upset. The usual adult dose for naproxen is 250 mg every 6 to 8 hours. Naproxen should not be taken for longer than 10 days unless directed by a physician. Naproxen may cause side effects such as stomach upset, constipation, or diarrhea. Naproxen should not be taken if you have a history of ulcers or gastrointestinal bleeding. Naproxen may also interact with other medications.

Difference Between Ibuprofen and Naproxen

Ibuprofen and Naproxen are both nonsteroidal anti-inflammatory drugs (NSAIDs). Ibuprofen is sold under many different brand names, including Advil and Motrin. Naproxen is sold under the brand name Aleve. Both drugs are effective at relieving pain and reducing inflammation. However, there are some key differences between the two drugs. Ibuprofen is available in both over-the-counter and prescription strength. Naproxen is only available by prescription. Ibuprofen is also broken down by the body more quickly than naproxen, which means it may be less effective for treating chronic conditions. Finally, ibuprofen can increase the risk of stomach ulcers, while naproxen has a lower risk of causing this side effect. As a result, it is important to speak with a doctor before choosing an either drug.


Ibuprofen and Naproxen are both NSAIDs, but they have different mechanisms of action. Naproxen is a prodrug that is converted to naproxen acid in the stomach. Naproxen acid inhibits prostaglandin synthesis by blocking cyclooxygenase-1 (COX-1) and COX-2 enzymes. Ibuprofen is a non-selective inhibitor of COX enzymes. This means it blocks both COX-1 and COX-2 enzymes. The difference between the two medications lies in their potency and duration of action. Naproxen is more potent than ibuprofen, but its duration of action is shorter.

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