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Difference between Glipizide and Metformin

Difference between Glipizide and Metformin

There are many different types of medications available to treat diabetes, and each medication has a specific purpose. Glipizide and Metformin are two common diabetes medications that are used to treat type 2 diabetes. Although they both serve the same purpose, there are some key differences between these two drugs. In this blog post, we will discuss the difference between Glipizide and Metformin, including how they work and their side effects.

What is Glipizide?

Glipizide is a medication that is used to treat type 2 diabetes. It works by helping the pancreas to produce more insulin, which helps to regulate blood sugar levels. Glipizide is typically taken once or twice a day, and it can be taken with or without food. Some common side effects of glipizide include headache, nausea, and dizziness. Glipizide is a prescription medication, and it is important to follow the instructions of your healthcare provider when taking this medication.

What is Metformin?

Metformin is a medication used to treat type 2 diabetes. It belongs to a class of drugs called biguanides. Metformin is typically taken two or three times a day with meals. Common side effects include diarrhea, nausea, and stomach pain.

  • Metformin can also cause low blood sugar levels. Metformin is available as a generic drug and as the brand-name drugs Glucophage, Glumetza, and Riomet. Metformin is usually the first medication prescribed for people with type 2 diabetes.
  • Metformin may be used alone or with other diabetes medications such as insulin, sulfonylureas, thiazolidinediones, and SOFAs. Metformin works by decreasing glucose production in the liver and by making it easier for your body to use insulin.
  • Metformin is not known to cause weight gain. In fact, some studies have shown that metformin may help people lose weight when used in combination with lifestyle changes such as diet and exercise. Metformin is generally well-tolerated.

The most common side effects are gastrointestinal, including diarrhea, nausea, vomiting, and stomach pain or cramping. If these side effects are severe or don’t go away, talk to your doctor or pharmacist about other options.

Difference between Glipizide and Metformin

Glipizide and metformin are two oral diabetes medications. They are often used together to treat type 2 diabetes.

  • Glipizide belongs to a class of drugs called sulfonylureas. It works by stimulating the pancreas to release insulin. Metformin belongs to a class of drugs called biguanides. It works by decreasing the amount of sugar that the liver produces and the intestines absorb. It also helps to make the body more sensitive to insulin.
  • Common side effects of glipizide include low blood sugar, headache, and nausea. Common side effects of metformin include headache, nausea, and diarrhea. Glipizide and metformin are both available as generic drugs. brand names for glipizide include Glucotrol and Glucotrol XL. brand names for metformin include Glucophage, Glumetza, Fortamet, Riomet, and Glucophage XR.
  • Glipizide and metformin are also available as combination drugs. brand names for these combination drugs include Glucovance, Metaglip, Avandamet, Janumet, Jentadueto, Kazano, Kombiglyze XR, Oleptro, Precose, Prandimet, Riomet Duo2, metaglip is also available as a liquid suspension.

Glipizide and metformin are also available as combination drugs with other oral diabetes medications such as pioglitazone (Actos) or linagliptin (Tradjenta).


Glipizide and Metformin are both medications used to treat type 2 diabetes. They work in different ways, so your doctor may prescribe one or the other depending on your individual situation. Let’s take a closer look at how these two drugs work and when they might be prescribed. Glipizide is a sulfonylurea drug that helps increase insulin production by the pancreas. It is often prescribed for people who have not been able to control their blood sugar levels with diet and exercise alone.

Metformin is a biguanide drug that helps the body use glucose more effectively. This drug is usually prescribed for people who have high blood sugar levels because their bodies do not produce enough insulin or cannot use insulin properly (insulin resistance). So, which of these two drugs is right for you? Talk to your doctor about what would be the best treatment plan for you.

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