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Difference between Adenine and Guanine

Difference between Adenine and Guanine

What are the chemical differences between adenine and guanine? What functions do they serve in cells? In this post, we will explore the answers to these questions and more. By understanding the role of each of these molecules in DNA and RNA, we can better understand how genetic information is transmitted and translated into proteins.

What is Adenine?

Adenine is one of the four bases that make up DNA. It is also found in RNA, but not in as high of concentrations. Adenine bonds with thymine in DNA and uracil in RNA. Adenine is a purine, which means that it has a double ring structure made up of nitrogen atoms. Adenine is named after one of the constituent bases of Adenine, adenine. Adenine is found in all living cells and is an important part of many biological processes. It is also used in some laboratory procedures. Adenine can be converted into other compounds, such as adenosine, which is used in metabolism. Adenine can also be recycled back into nucleotides. Adenine is essential for life and plays a vital role in many cellular processes.

What is Guanine?

Guanine is one of the five main nucleobases in the nucleic acids DNA and RNA, called purine. In DNA, guanine is paired with cytosine. The structure of guanine is a planar fused-ring system composed of an imidazole ring fused to a substituted pyrimidine ring. Guanine has two valence electrons available for binding and forming hydrogen bonds. At pH 7, its free base Guanine has a pKa of about 5.2.

Guanine can be converted to hypoxanthine by loss of H+ from C5′, and this occurs during cellular metabolism independent of deoxyribonucleotide synthesis or salvage. Guanines can also be acylated on position N7 by alkyl Guanines to form N7-substituted guanines (for example, N7-methylguanine), which are found in modified base residues in some RNA species including transfer RNAs (tRNAs), ribosomal RNAs (rRNAs) and small nuclear RNAs (snRNAs).

Difference between Adenine and Guanine

Adenine (A) and Guanine (G) are two of the four nucleobases found in DNA. Adenine always pairs with thymine (T), while guanine always pairs with cytosine (C). Adenine and guanine are purines, while thymine and cytosine are pyrimidines. Adenine is larger than guanine, with a molecular weight of 135 g/mol compared to guanine’s 150 g/mol. Adenine is also slightly less soluble in water than guanine; adenine has a solubility of 12 g/L compared to guanine’s 14 g/L. Finally, adenine has a higher melting point than guanine; adenine melts at 247 degrees Celsius, while guanine melts at 213 degrees Celsius.


Adenine and Guanine are two of the four nitrogenous bases that make up DNA. They differ in the number of hydrogen bonds they form with complementary base pairs. Adenine always pairs with Thymine, while Guanine always pairs with Cytosine. These differences play an important role in genetic replication and transcription.

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